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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FOSTEMSAVIR (has an active metabolite)
| FOSTEMSAVIR | ANTIINFECTIVES | ORAL | SOLUBILITY SOLUBLE IN WATER (> 250 MILLIGRAM PER MILLILITER) | HIV-1 GP120 | Envelope glycoprotein gp160 UNIPROT Q75760 env more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TEMSAVIR (is an active metabolite)
| TEMSAVIR | ANTIINFECTIVES | - | Cmax 3.74 MICROMOLAR Tmax 2 HOUR F 26.9 PERCENT VD 29.5 LITER PPB 88.4 PERCENT Cl 66.4 LITER / HOUR HT 11 HOUR | HIV-1 GP120 PDB 5U7O (CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR BMS-626529 IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 3.8 ANGSTROM) LIGAND CODE = 83J (link to the list of PDB complexes) Download experimental 3D coordinates of 83J with added hydrogens | Envelope glycoprotein gp160 UNIPROT Q75760 env more at DrugCentral | EMA | |||
