Cheminformatic Tools and Databases for Pharmacology

session 22766 - Total of 3 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DAROLUTAMIDE (has an active metabolite)

DAROLUTAMIDE


ATC L02BB06

ANTINEOPLASTIC
ANDROGEN RECEPTOR INHIBITOR
TREATMENT OF NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

ORAL

Cmax 12 MICROMOLAR

Tmax 4 HOUR

F 30 PERCENT

VD 119 LITER

PPB 92 PERCENT

Cl 6.96 LITER / HOUR

HT 20 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS MEDIUM

ANDROGEN RECEPTOR (AR)

Androgen receptor inhibitor P10275 (ANDR_HUMAN)EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DAROLUTAMIDE (has an active metabolite)

DAROLUTAMIDE


ATC L02BB06

ANTINEOPLASTIC
ANDROGEN RECEPTOR INHIBITOR
TREATMENT OF NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

ORAL

Cmax 12 MICROMOLAR

Tmax 4 HOUR

F 30 PERCENT

VD 119 LITER

PPB 92 PERCENT

Cl 6.96 LITER / HOUR

HT 20 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS MEDIUM

ANDROGEN RECEPTOR (AR)

Androgen receptor inhibitor P10275 (ANDR_HUMAN)EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

3 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M DAROLUTAMIDE (is an active metabolite)

DAROLUTAMIDE


ATC L02BB06

ANTINEOPLASTIC
ANDROGEN RECEPTOR INHIBITOR
TREATMENT OF NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

-

PPB 99.8 PERCENT

HT 20 HOUR

ANDROGEN RECEPTOR (AR)

Androgen receptor inhibitor P10275 (ANDR_HUMAN)EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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