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session 67138 - Total of 2 hits - Display hits per page:

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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M PIMAVANSERIN (is an active metabolite)	PIMAVANSERIN	ATC N05AX17 NERVOUS SYSTEM ANTIPSYCHOTIC TREATMENT OF HALLUCINATIONS AND DELUSIONS ASSOCIATED WITH PARKINSON'S DISEASE PSYCHOSIS INVERSE AGONIST / ANTAGONIST SEROTONIN 5-HT2A (KI = 0.087 NANOMOLAR) AND 5-HT2C (KI = 0.44 NANOMOLAR) SIGMA 1 RECEPTOR (KI = 120 NANOMOLAR)	-	HT 200 HOUR	5-HT2A RECEPTOR 5-HT2C RECEPTOR	5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
PIMAVANSERIN (has an active metabolite)	PIMAVANSERIN	ATC N05AX17 NERVOUS SYSTEM ANTIPSYCHOTIC TREATMENT OF HALLUCINATIONS AND DELUSIONS ASSOCIATED WITH PARKINSON'S DISEASE PSYCHOSIS INVERSE AGONIST / ANTAGONIST SEROTONIN 5-HT2A (KI = 0.087 NANOMOLAR) AND 5-HT2C (KI = 0.44 NANOMOLAR) SIGMA 1 RECEPTOR (KI = 120 NANOMOLAR)	ORAL	Tmax 6 HOUR VD 2173 LITER PPB 95 PERCENT HT 57 HOUR SOLUBILITY SOLUBLE IN WATER	5-HT2A RECEPTOR 5-HT2C RECEPTOR	5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank