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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESTRADIOL (is an active metabolite) (has an active metabolite)
| ESTRADIOL |
GENITO | TRANSDERMAL VAGINAL ORAL TOPICAL INJECTION | Cmax 639.7 PICOMOLAR Tmax 1 HOUR VD 78 LITER (65 KILOGRAM) PPB 98.4 PERCENT Cl 117 LITER / HOUR (65 KILOGRAM) HT 1.7 HOUR | ESTROGEN RECEPTOR PDB 1FDU (HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH ESTRADIOL AND NADP+) LIGAND CODE = EST (link to the list of PDB complexes) Download experimental 3D coordinates of EST with added hydrogens | Estrogen receptor UNIPROT P03372 ESR1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESTRONE DISCONTINUED (is an active metabolite)
| ESTRONE | NATURAL MOLECULE (link) GENITO | INJECTION | Cmax 1.03 NANOMOLAR Tmax 4 HOUR SOLUBILITY SOLUBLE IN WATER | ESTROGEN RECEPTOR PDB 3HM1 (CRYSTAL STRUCTURE OF HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE AND ESTRONE ((8R,9S,13S,14S)-3-HYDROXY-13-METHYL-7,8,9,11,12,14,15,16-OCTAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-ONE)) LIGAND CODE = J3Z (link to the list of PDB complexes) Download experimental 3D coordinates of J3Z with added hydrogens | Estrogen receptor UNIPROT P03372 ESR1 more at DrugCentral | EMA | |||
