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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PREDNISOLONE (is an active metabolite)
| PREDNISOLONE |
METABOLISM | ORAL TOPICAL OPHTHALMIC OTIC INJECTION | Cmax 1.28 MICROMOLAR Tmax 1.5 HOUR VD 29.9 LITER (65 KILOGRAM) PPB 80 PERCENT Cl 11.3 LITER / HOUR (65 KILOGRAM) HT 2.5 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | GLUCOCORTICOID RECEPTOR PDB 6W9K (STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH PREDNISOLONE AND PGC1A COREGULATOR FRAGMENT) LIGAND CODE = TUA (link to the list of PDB complexes) Download experimental 3D coordinates of TUA with added hydrogens | Glucocorticoid receptor UNIPROT P04150 NR3C1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PREDNISOLONE ACETATE (has an active metabolite)
| PREDNISOLONE ACETATE |
METABOLISM | OPHTHALMIC INJECTION ORAL | SOLUBILITY INSOLUBLE IN WATER | GLUCOCORTICOID RECEPTOR | Glucocorticoid receptor UNIPROT P04150 NR3C1 more at DrugCentral | EMA | |||
