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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LOVASTATIN (has an active metabolite)
| LOVASTATIN | NATURAL MOLECULE (link) CARDIOVASCULAR | ORAL | Cmax 19.3 NANOMOLAR Tmax 2 HOUR F 30 PERCENT PPB 95 PERCENT HT 4.5 HOUR SOLUBILITY INSOLUBLE IN WATER | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE PDB 1CQP (CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION) LIGAND CODE = 803 (link to the list of PDB complexes) Download experimental 3D coordinates of 803 with added hydrogens | HMG-COA REDUCTASE INHIBITOR CHEMBL402 HMG-COA REDUCTASE P04035 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE HOMO SAPIENS ENZYME REDUCTASE | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M LOVASTATIN (is an active metabolite)
| LOVASTATIN | CARDIOVASCULAR | - | Cmax 28.1 NANOMOLAR Tmax 3 HOUR VD 56.5 LITER (65 KILOGRAM) PPB 95 PERCENT Cl 28 LITER / HOUR (65 KILOGRAM) HT 1.4 HOUR | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE PDB 3HLG (SIMVASTATIN SYNTHASE (LOVD), FROM ASPERGILLUS TERREUS, S5 MUTANT, S76A MUTANT, COMPLEX WITH LOVASTATIN) LIGAND CODE = LVA (link to the list of PDB complexes) Download experimental 3D coordinates of LVA with added hydrogens | HMG-COA REDUCTASE INHIBITOR CHEMBL402 HMG-COA REDUCTASE P04035 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE HOMO SAPIENS ENZYME REDUCTASE | EMA | |||
