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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LAMIVUDINE (has an active metabolite)
| LAMIVUDINE |
ANTIINFECTIVES | ORAL | Cmax 15.1 MICROMOLAR (300 MILLIGRAM) PMID11605717 Tmax 1.3 HOUR F 87 PERCENT VD 84.5 LITER (65 KILOGRAM) PPB 36 PERCENT Cl 23.9 LITER / HOUR HT 6 HOUR SOLUBILITY OF 70 MILLIGRAM / MILLILITER IN WATER | REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) PDB 2NOA (THE STRUCTURE OF DEOXYCYTIDINE KINASE COMPLEXED WITH LAMIVUDINE AND ADP.) LIGAND CODE = 3TC (link to the list of PDB complexes) Download experimental 3D coordinates of 3TC with added hydrogens | Protein P UNIPROT Q9IF40 P -- Reverse transcriptase,RNaseH UNIPROT Q72547 pol more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M LAMIVUDINE (is an active metabolite)
| LAMIVUDINE |
ANTIINFECTIVES | - | REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) PDB 4K4H (TERNARY CRYSTAL STRUCTURES OF A HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND (-)3TC-TP.) LIGAND CODE = 1RZ (link to the list of PDB complexes) Download experimental 3D coordinates of 1RZ with added hydrogens | Protein P UNIPROT Q9IF40 P -- Reverse transcriptase,RNaseH UNIPROT Q72547 pol more at DrugCentral | EMA | ||||
