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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ADEFOVIR (is an active metabolite)
| ADEFOVIR | ANTIINFECTIVES | - | Cmax 36.7 NANOMOLAR Tmax 1.75 HOUR F 59 PERCENT VD 25.4 LITER (65 KILOGRAM) PPB 4 PERCENT Cl 14.4 LITER / HOUR (65 KILOGRAM) HT 7.48 HOUR | HBV REVERSE TRANSCRIPTASE PDB 2G1A (CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN APHA CLASS B ACID PHOSPHATASE, PHOSPHOTRANSFERASE) LIGAND CODE = 5HG (link to the list of PDB complexes) Download experimental 3D coordinates of 5HG with added hydrogens | Protein P UNIPROT Q9IF40 P more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ADEFOVIR DIPIVOXIL (has an active metabolite)
| ADEFOVIR DIPIVOXIL | ANTIINFECTIVES | ORAL | SOLUBILITY 0.4 MILLIGRAM / MILLILITER AT PH 7.2 | HBV REVERSE TRANSCRIPTASE | Protein P UNIPROT Q9IF40 P more at DrugCentral | EMA | |||
