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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLUOXETINE (has an active metabolite)
| FLUOXETINE | NERVOUS SYSTEM | ORAL | Cmax 178 NANOMOLAR Tmax 7 HOUR VD 1950 LITER (65 KILOGRAM) PPB 94.5 PERCENT HT 120 HOUR SOLUBILITY 14 MILLIGRAM / MILLILITER | SODIUM-DEPENDENT SEROTONIN TRANSPORTER POTASSIUM CHANNEL TREKS PDB 3GWW (LEUCINE TRANSPORTER LEUT IN COMPLEX WITH S-FLUOXETINE) LIGAND CODE = SFX (link to the list of PDB complexes) Download experimental 3D coordinates of SFX with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLUOXETINE (has an active metabolite)
| FLUOXETINE | NERVOUS SYSTEM | ORAL | Cmax 178 NANOMOLAR Tmax 7 HOUR VD 1950 LITER (65 KILOGRAM) PPB 94.5 PERCENT HT 120 HOUR SOLUBILITY 14 MILLIGRAM / MILLILITER | SODIUM-DEPENDENT SEROTONIN TRANSPORTER POTASSIUM CHANNEL TREKS PDB 4MM8 (CRYSTAL STRUCTURE OF LEUBAT (DELTA13 MUTANT) IN COMPLEX WITH (R)-FLUOXETINE) LIGAND CODE = RFX (link to the list of PDB complexes) Download experimental 3D coordinates of RFX with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral | EMA | |||
| 3 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NORFLUOXETINE (is an active metabolite)
| NORFLUOXETINE | NERVOUS SYSTEM | - | Cmax 559 NANOMOLAR HT 240 HOUR | SODIUM-DEPENDENT SEROTONIN TRANSPORTER PDB 4XDK (CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN COMPLEX WITH NORFLUOXETINE) LIGAND CODE = 408 (link to the list of PDB complexes) Download experimental 3D coordinates of 408 with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral | EMA | |||
