Browse e-DRUG3D database

Cheminformatic Tools and Databases for Pharmacology
Home	e-Drug3D	LEA3D	SENSAAS	IPMC

session 48543 - Total of 2 hits - Display hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)


1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
ICOSAPENT (is an active metabolite)	ICOSAPENT	NATURAL MOLECULE (link) CARDIOVASCULAR ADJUNCT TO DIET TO REDUCE TRIGLYCERIDE (TG) LEVELS IN ADULT PATIENTS WITH SEVERE (>= 500 MG/DL) HYPERTRIGLYCERIDEMIA POTENTIAL MECHANISMS OF ACTION INCLUDE INCREASED BETA-OXIDATION INHIBITION OF ACYL-COA:1,2-DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) DECREASED LIPOGENESIS IN THE LIVER AND INCREASED PLASMA LIPOPROTEIN LIPASE ACTIVITY	-	VD 88 LITER PPB 99 PERCENT Cl 0.68 LITER / HOUR HT 89 HOUR	PDB 1IGX (CRYSTAL STRUCTURE OF EICOSAPENTANOIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.) LIGAND CODE = EPA (link to the list of PDB complexes) Download experimental 3D coordinates of EPA with added hydrogens	Unknown more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
ICOSAPENT ETHYL (has an active metabolite)	ICOSAPENT ETHYL	CARDIOVASCULAR ADJUNCT TO DIET TO REDUCE TRIGLYCERIDE (TG) LEVELS IN ADULT PATIENTS WITH SEVERE (>= 500 MG/DL) HYPERTRIGLYCERIDEMIA POTENTIAL MECHANISMS OF ACTION INCLUDE INCREASED BETA-OXIDATION INHIBITION OF ACYL-COA:1,2-DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) DECREASED LIPOGENESIS IN THE LIVER AND INCREASED PLASMA LIPOPROTEIN LIPASE ACTIVITY	ORAL			Diacylglycerol O-acyltransferase 1 UNIPROT O75907 DGAT1 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank