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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DOLASETRON DISCONTINUED (has an active metabolite)
| DOLASETRON | METABOLISM | ORAL INJECTION | SOLUBILITY SLIGHTLY SOLUBLE IN NORMAL SALINE | 5-HYDROXYTRYPTAMINE 3 RECEPTOR | 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M DOLASETRON (is an active metabolite)
| DOLASETRON | METABOLISM | - | Cmax 1.7 MICROMOLAR (200 MILLIGRAM) F 75 PERCENT VD 377 LITER (65 KILOGRAM) PPB 77 PERCENT Cl 52 LITER / HOUR (65 KILOGRAM) HT 8.1 HOUR | 5-HYDROXYTRYPTAMINE 3 RECEPTOR | 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A more at DrugCentral | EMA | |||
