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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DOXERCALCIFEROL (has an active metabolite)
| DOXERCALCIFEROL | HORMONES | ORAL INJECTION | SOLUBILITY RELATIVELY INSOLUBLE IN WATER | VITAMIN D3 RECEPTOR PDB 3DL9 (CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITH 1-ALPHA-HYDROXY-VITAMIN D2) LIGAND CODE = V2H (link to the list of PDB complexes) Download experimental 3D coordinates of V2H with added hydrogens | Vitamin D3 receptor UNIPROT P11473 VDR more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M DOXERCALCIFEROL (is an active metabolite)
| DOXERCALCIFEROL | HORMONES | - | Tmax 8 HOUR HT 34.5 HOUR | VITAMIN D3 RECEPTOR | Vitamin D3 receptor UNIPROT P11473 VDR more at DrugCentral | EMA | |||
