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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M TAFLUPROST (is an active metabolite)
| TAFLUPROST | OPEN-ANGLE GLAUCOMA | - | Cmax 0.0634 NANOMOLAR (ONE DROP 0.0015 PERCENT) Tmax 0.16 HOUR PPB 99 PERCENT | FP PROSTANOID RECEPTOR PDB 8IUM (CRYO-EM STRUCTURE OF THE TAFLUPROST ACID-BOUND HUMAN PTGFR-GQ COMPLEX) LIGAND CODE = S2F (link to the list of PDB complexes) Download experimental 3D coordinates of S2F with added hydrogens | Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TAFLUPROST (has an active metabolite)
| TAFLUPROST | SENSORY | OPHTHALMIC | SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | FP PROSTANOID RECEPTOR | Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR more at DrugCentral | EMA | |||
