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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FIDAXOMICIN (has an active metabolite)
| FIDAXOMICIN | ANTIINFECTIVES | ORAL | Cmax 4.9 NANOMOLAR (200 MILLIGRAM) Tmax 2 HOUR HT 11.7 HOUR | BETA SUBUNIT OF RNA POLYMERASE PDB 6BZO (MTB RNAP HOLO, RBPA, FIDAXOMICIN, UPSTREAM FORK DNA) LIGAND CODE = FI8 (link to the list of PDB complexes) Download experimental 3D coordinates of FI8 with added hydrogens | DNA-directed RNA polymerase UNIPROT Q182S6 rpoZ more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M FIDAXOMICIN (is an active metabolite)
| FIDAXOMICIN | ANTIINFECTIVES | - | Cmax 12.1 NANOMOLAR (200 MILLIGRAM) Tmax 1.02 HOUR HT 11.2 HOUR | BETA SUBUNIT OF RNA POLYMERASE | DNA-directed RNA polymerase UNIPROT Q182S6 rpoZ more at DrugCentral | EMA | |||
