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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M ULIPRISTAL ACETATE (is an active metabolite)
| ULIPRISTAL ACETATE | GENITO | - | Cmax 159.3 NANOMOLAR HT 27 HOUR | PROGESTERONE RECEPTOR | Progesterone receptor UNIPROT P06401 PGR more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ULIPRISTAL ACETATE (has an active metabolite)
| ULIPRISTAL ACETATE | GENITO | ORAL | Cmax 370.5 NANOMOLAR Tmax 0.9 HOUR PPB 94 PERCENT Cl 76.8 LITER / HOUR HT 32 HOUR | PROGESTERONE RECEPTOR PDB 4OAR (PROGESTERONE RECEPTOR WITH BOUND ULIPRISTAL ACETATE AND A PEPTIDE FROM THE CO-REPRESSOR SMRT) LIGAND CODE = 2S0 (link to the list of PDB complexes) Download experimental 3D coordinates of 2S0 with added hydrogens | Progesterone receptor UNIPROT P06401 PGR more at DrugCentral | EMA | |||
