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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| HALOPERIDOL (is an active metabolite)
| HALOPERIDOL | NERVOUS SYSTEM | ORAL INJECTION | Cmax 15.3 NANOMOLAR Tmax 4 HOUR F 60 PERCENT VD 1105 LITER (65 KILOGRAM) PPB 92 PERCENT Cl 30.4 LITER / HOUR (65 KILOGRAM) HT 35 HOUR | D(1A) DOPAMINE RECEPTOR D(2) DOPAMINE RECEPTOR PDB 6DJZ (HUMAN SIGMA-1 RECEPTOR BOUND TO HALOPERIDOL) LIGAND CODE = GMJ (link to the list of PDB complexes) Download experimental 3D coordinates of GMJ with added hydrogens | D(2) dopamine receptor UNIPROT P14416 DRD2 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| HALOPERIDOL DECANOATE (has an active metabolite)
| HALOPERIDOL DECANOATE | NERVOUS SYSTEM | INJECTION | SOLUBILITY ALMOST INSOLUBLE IN WATER 0.01 MILLIGRAM / MILLILITER | DOPAMINE D2 RECEPTOR | D(2) dopamine receptor UNIPROT P14416 DRD2 -- D(2) dopamine receptor UNIPROT P14416 DRD2 more at DrugCentral | EMA | |||
