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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M QUETIAPINE (is an active metabolite)	QUETIAPINE	ATC N05AH04 NERVOUS SYSTEM ANTIPSYCHOTIC SCHIZOPHRENIA DIBENZOTHIAZEPINE FAMILY DOPAMINE D2 RECEPTOR ANTAGONIST (IC50=329 NANOMOLAR) SEROTONIN (5HT2) ANTAGONIST (IC50=148 NANOMOLAR) SEROTONIN 5HT1A ANTAGONIST (IC50=717 NANOMOLAR) DOPAMINE D1 ANTAGONIST (IC50=1268 NANOMOLAR) HISTAMINE H1 ANTAGONIST (IC50=30 NANOMOLAR) ADRENERGIC ALPHA 1 RECEPTOR ANTAGONIST (IC50= 94 NANOMOLAR) ADRENARGIC ALPHA 2 RECEPTOR ANTAGONIST (IC50=271 NANOMOLAR) NO APPRECIABLE AFFINITY AT CHOLINERGIC MUSCARINIC AND BENZODIAZEPINE RECEPTORS (IC50 SUPERIOR TO 5000 NANOMOLAR)	-		5-HYDROXYTRYPTAMINE 2 RECEPTOR D2 DOPAMINE RECEPTOR	D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
QUETIAPINE (has an active metabolite)	QUETIAPINE	ATC N05AH04 NERVOUS SYSTEM ANTIPSYCHOTIC SCHIZOPHRENIA DIBENZOTHIAZEPINE FAMILY DOPAMINE D2 RECEPTOR ANTAGONIST (IC50=329 NANOMOLAR) SEROTONIN (5HT2) ANTAGONIST (IC50=148 NANOMOLAR) SEROTONIN 5HT1A ANTAGONIST (IC50=717 NANOMOLAR) DOPAMINE D1 ANTAGONIST (IC50=1268 NANOMOLAR) HISTAMINE H1 ANTAGONIST (IC50=30 NANOMOLAR) ADRENERGIC ALPHA 1 RECEPTOR ANTAGONIST (IC50= 94 NANOMOLAR) ADRENARGIC ALPHA 2 RECEPTOR ANTAGONIST (IC50=271 NANOMOLAR) NO APPRECIABLE AFFINITY AT CHOLINERGIC MUSCARINIC AND BENZODIAZEPINE RECEPTORS (IC50 SUPERIOR TO 5000 NANOMOLAR)	ORAL	F 100 PERCENT VD 650 LITER (65 KILOGRAM) PPB 83 PERCENT Cl 75 LITER / HOUR (EQN) HT 6 HOUR SOLUBILITY MODERATELY SOLUBLE IN WATER	5-HYDROXYTRYPTAMINE 2 RECEPTOR D2 DOPAMINE RECEPTOR	D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank