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session 26371 - Total of 3 hits - Display hits per page:

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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
DROXIDOPA (has an active metabolite)	DROXIDOPA	ATC C01CA27 CARDIOVASCULAR TREATMENT OF ORTHOSTATIC DIZZINESS AND LIGHTHEADEDNESS SYNTHETIC AMINO ACID PRECURSOR OF NOREPINEPHRINE SUBSTRATE OF DOPA-DECARBOXYLASE	ORAL	Tmax 2 HOUR VD 200 LITER PPB 75 PERCENT Cl 55.4 LITER / HOUR (EQN) HT 2.5 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER	DOPA-DECARBOXYLASE	Adrenergic receptor UNIPROT P07550 ADRB2 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
EPHEDRINE (has an active metabolite)	EPHEDRINE	NATURAL MOLECULE (link) ATC C01CA26 ATC R01AA03 ATC R01AB05 ATC R03CA02 ATC S01FB02 ATC A08AA56 RESPIRATORY SYMPATHOMIMETIC ALPHA AND BETA ADRENERGIC AGONIST NOREPINEPHRINE RELEASING AGENT TREATMENT OF CLINICALLY IMPORTANT HYPOTENSION OCCURRING IN THE SETTING OF ANESTHESIA METABOLIZED INTO NOREPHEDRINE	INTRAVENOUS	HT 6 HOUR SOLUBILITY FREELY SOLUBLE IN WATER	ALPHA ADRENERGIC RECEPTOR BETA ADRENERGIC RECEPTOR	Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
3	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
NOREPINEPHRINE (is an active metabolite)	NOREPINEPHRINE	NATURAL MOLECULE (link) ATC C01CA03 CARDIOVASCULAR ADRENERGIC RECEPTOR AGONIST SYMPATHOMIMETICS VASOCONSTRICTOR AGENTS PERIPHERAL VASOCONSTRICTOR (ALPHA-ADRENERGIC ACTION) AND AS AN INOTROPIC STIMULATOR OF THE HEART AND DILATOR OF CORONARY ARTERIES (BETA-ADRENERGIC ACTION)	INJECTION INTRAVENOUS	SOLUBILITY SPARINGLY SOLUBLE IN WATER	ADRENERGIC RECEPTORS PDB 3HCD (CRYSTAL STRUCTURE OF HPNMT IN COMPLEX WITH NORADRENALINE AND ADOHCY) LIGAND CODE = LNR (link to the list of PDB complexes) Download experimental 3D coordinates of LNR with added hydrogens	Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank