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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ARTEMETHER (has an active metabolite)
| ARTEMETHER | ANTIPARASITIC | ORAL | Cmax 201 NANOMOLAR Tmax 2 HOUR PPB 95.4 PERCENT HT 2 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PDB 6FGD (CRYSTAL STRUCTURE OF GEPHYRIN E DOMAIN IN COMPLEX WITH ARTEMETHER) LIGAND CODE = D8Z (link to the list of PDB complexes) Download experimental 3D coordinates of D8Z with added hydrogens | FERRIPROTOPORPHYRIN IX INHIBITOR CHEMBL613897 FERRIPROTOPORPHYRIN IX PLASMODIUM FALCIPARUM | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ARTESUNATE (has an active metabolite)
| ARTESUNATE |
ANTIINFECTIVES | INTRAVENOUS | Cmax 8.6 MICROMOLAR VD 68.5 LITER PPB 93 PERCENT Cl 180 LITER / HOUR HT 0.3 HOUR | PDB 6FGC (CRYSTAL STRUCTURE OF GEPHYRIN E DOMAIN IN COMPLEX WITH ARTESUNATE) LIGAND CODE = D95 (link to the list of PDB complexes) Download experimental 3D coordinates of D95 with added hydrogens | Unknown - more at DrugCentral | EMA | |||
| 3 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DIHYDROARTEMISININ (is an active metabolite)
| DIHYDROARTEMISININ | ANTIPARASITIC | - | Cmax 366 NANOMOLAR Tmax 2 HOUR PPB 61 PERCENT HT 2 HOUR | Unknown - more at DrugCentral | EMA | ||||
