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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MYCOPHENOLATE MOFETIL (has an active metabolite)
| MYCOPHENOLATE MOFETIL | IMMUNOSUPPRESSANTS | ORAL INJECTION | F 94 PERCENT SOLUBILITY SLIGHTLY SOLUBLE IN WATER (43 MICROGRAM / MILLILITER AT PH 7.4) | INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) | Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1 -- Inosine-5-monophosphate dehydrogenase 2 UNIPROT P12268 IMPDH2 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MYCOPHENOLIC ACID (is an active metabolite)
| MYCOPHENOLIC ACID | NATURAL MOLECULE (link) IMMUNOMODULATING AGENT | ORAL | Cmax 81.5 MICROMOLAR F 93 PERCENT VD 112 LITER PPB 98 PERCENT Cl 8.4 LITER / HOUR HT 12 HOUR SOLUBILITY HIGHLY SOLUBLE IN WATER | INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) PDB 4FXS (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE FROM VIBRIO CHOLERAE COMPLEXED WITH IMP AND MYCOPHENOLIC ACID) LIGAND CODE = MOA (link to the list of PDB complexes) Download experimental 3D coordinates of MOA with added hydrogens | Inosine-5-monophosphate dehydrogenase (IMPDH) UNIPROT P12268 IMPDH2 more at DrugCentral | EMA | |||
