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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMPICILLIN (is an active metabolite)
| AMPICILLIN |
ANTIINFECTIVES | INJECTION INTRAVENOUS ORAL | Cmax 429 MICROMOLAR (2 GRAM IV) Tmax 0.25 HOUR VD 14 LITER (65 KILOGRAM) PPB 28 PERCENT Cl 10.9 LITER / HOUR (65 KILOGRAM) HT 1 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | PENICILLIN-BINDING PROTEINS 1A/1B PDB 3NDV (CRYSTAL STRUCTURE OF THE N-TERMINAL BETA-AMINOPEPTIDASE BAPA IN COMPLEX WITH AMPICILLIN) LIGAND CODE = AIC (link to the list of PDB complexes) Download experimental 3D coordinates of AIC with added hydrogens | Bacterial penicillin-binding protein UNIPROT P02918 mrcA more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BACAMPICILLIN DISCONTINUED (has an active metabolite)
| BACAMPICILLIN | ANTIINFECTIVES | ORAL | PENICILLIN-BINDING PROTEINS 1A/1B | Bacterial penicillin-binding protein UNIPROT P02918 mrcA more at DrugCentral | EMA | ||||
