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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PROBENECID

PROBENECID


ATC M04AC51
ATC M04AB01

METABOLISM
URICOSURIC AGENT
RENAL TUBULAR BLOCKING AGENT

ORAL

VD 8.4 LITER (65 KILOGRAM)

PPB 97 PERCENT

Cl 0.97 LITER / HOUR (65 KILOGRAM)

HT 5.9 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

ORGANIC ANION TRANSPORTER

PDB 8BVT (CRYO-EM STRUCTURE OF RAT SLC22A6 BOUND TO PROBENECID)

LIGAND CODE = RTO (link to the list of PDB complexes)

Download experimental 3D coordinates of RTO with added hydrogens

Solute carrier family 22 member 6 UNIPROT Q4U2R8 SLC22A6 -- Solute carrier family 22 member 8 UNIPROT Q8TCC7 SLC22A8

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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