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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MARAVIROC
| MARAVIROC | ANTIINFECTIVES | ORAL | Cmax 1.73 MICROMOLAR (300 MILLIGRAM TWICE DAILY ORAL) Tmax 2.25 HOUR F 28 PERCENT VD 194 LITER PPB 76 PERCENT Cl 8.4 LITER / HOUR (EQN) HT 16 HOUR SOLUBILITY HIGHLY SOLUBLE IN WATER | C-C CHEMOKINE RECEPTOR TYPE 5 PDB 4MBS (CRYSTAL STRUCTURE OF THE CCR5 CHEMOKINE RECEPTOR) LIGAND CODE = MRV (link to the list of PDB complexes) Download experimental 3D coordinates of MRV with added hydrogens | C-C chemokine receptor type 5 UNIPROT P51681 CCR5 more at DrugCentral | EMA | |||
