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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DORIPENEM DISCONTINUED

DORIPENEM


ATC J01DH04

ANTIINFECTIVES
ANTIBACTERIALS
SYNTHETIC BROAD-SPECTRUM CARBAPENEM ANTIBIOTIC
INHIBITS BACTERIAL CELL WALL BIOSYNTHESIS

INTRAVENOUS

Cmax 54.7 MICROMOLAR (500 MILLIGRAM)

Tmax 1 HOUR

VD 16.8 LITER

PPB 8 PERCENT

Cl 15.9 LITER / HOUR

HT 1 HOUR

PENICILLIN-BINDING PROTEIN

PDB 6P9C (OXA-48 CARBAPANEMASE, DORIPENEM COMPLEX)

LIGAND CODE = O6P (link to the list of PDB complexes)

Download experimental 3D coordinates of O6P with added hydrogens

Bacterial penicillin-binding protein UNIPROT P02918 mrcA

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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