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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
VARENICLINE

VARENICLINE


ATC N07BA03
ATC S01XA28

NERVOUS SYSTEM
NICOTINIC AGONISTS
USE AS AN AID TO SMOKING CESSATION TREATMENT

ORAL NASAL

Tmax 3.5 HOUR

F 90 PERCENT

VD 415 LITER

PPB 20 PERCENT

HT 24 HOUR

SOLUBILITY HIGHLY SOLUBLE IN WATER

NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 BETA-2
5-HT3 RECEPTOR (KI=350 NANOMOLAR)

PDB 5AIN (VARENICLINE INTERACTIONS AT THE 5HT3 RECEPTOR LIGAND BINDING SITE ARE REVEALED BY 5HTBP)

LIGAND CODE = QMR (link to the list of PDB complexes)

Download experimental 3D coordinates of QMR with added hydrogens

Neuronal acetylcholine receptor

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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