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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ARFORMOTEROL
| ARFORMOTEROL | RESPIRATORY | INHALATION | Cmax 0.0125 NANOMOLAR (15 MICROGRAM EVERY 12 HOURS) Tmax 0.5 HOUR PPB 58.5 PERCENT HT 13 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | BETA-2 ADRENERGIC RECEPTOR PDB 6IBL (ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY NB80) LIGAND CODE = H98 (link to the list of PDB complexes) Download experimental 3D coordinates of H98 with added hydrogens | Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 more at DrugCentral | EMA | |||
