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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RAMELTEON
| RAMELTEON | NERVOUS SYSTEM | ORAL | Tmax 0.75 HOUR F 1.8 PERCENT VD 73.6 LITER PPB 82 PERCENT Cl 28.3 LITER / HOUR (EQN) HT 1.8 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | MELATONIN RECEPTOR MT1 MELATONIN RECEPTOR MT2 PDB 6ME2 (XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT1 IN COMPLEX WITH RAMELTEON) LIGAND CODE = JEV (link to the list of PDB complexes) Download experimental 3D coordinates of JEV with added hydrogens | Melatonin receptor type 1A UNIPROT P48039 MTNR1A -- Melatonin receptor type 1B UNIPROT P49286 MTNR1B more at DrugCentral | EMA | |||
