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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ALVIMOPAN
| ALVIMOPAN | METABOLISM | ORAL | Cmax 25.8 NANOMOLAR Tmax 2 HOUR F 6 PERCENT VD 30 LITER PPB 80 PERCENT Cl 24 LITER / HOUR HT 14 HOUR SOLUBILITY LESS THAN 0.1 MILLIGRAM / MILLILITER IN WATER | MU-TYPE OPIOID RECEPTOR PDB 7UL4 (CRYOEM STRUCTURE OF INACTIVE MOR BOUND TO ALVIMOPAN AND MB6) LIGAND CODE = NG0 (link to the list of PDB complexes) Download experimental 3D coordinates of NG0 with added hydrogens | Mu-type opioid receptor UNIPROT P35372 OPRM1 more at DrugCentral | EMA | |||
