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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BORTEZOMIB
| BORTEZOMIB | ANTINEOPLASTIC AGENTS | INTRAVENOUS SUBCUTANEOUS INJECTION | Cmax 321.7 NANOMOLAR VD 1917 LITER PPB 83 PERCENT Cl 32 LITER / HOUR HT 92 HOUR | 26S PROTEASOME PDB 4QW1 (YCP BETA5-A50V MUTANT IN COMPLEX WITH BORTEZOMIB) LIGAND CODE = BO2 (link to the list of PDB complexes) Download experimental 3D coordinates of BO2 with added hydrogens | Proteasome subunit alpha type-1 UNIPROT P25786 PSMA1 -- Proteasome subunit beta type-8 UNIPROT P28062 PSMB8 more at DrugCentral | EMA | |||
