APREPITANT (is an active metabolite) | APREPITANT | ATC A04AD12
METABOLISM ANTIEMETICS P/NEUROKININ-1 (NK1) RECEPTOR ANTAGONIST APREPITANT HAS LITTLE OR NO AFFINITY FOR SEROTONIN (5-HT3), DOPAMINE, AND CORTICOSTEROID RECEPTORS | ORAL INTRAVENOUS | Cmax 6.9 MICROMOLAR VD 70 LITER PPB 95 PERCENT Cl 4.4 LITER / HOUR (EQN) HT 11 HOUR | P/NEUROKININ-1 (NK1) RECEPTOR PDB 6HLO (CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST APREPITANT) LIGAND CODE = GBQ (link to the list of PDB complexes) Download experimental 3D coordinates of GBQ with added hydrogens | Substance-P receptor UNIPROT P25103 TACR1 more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |