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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MEMANTINE
| MEMANTINE |
NERVOUS SYSTEM | ORAL | Tmax 5 HOUR VD 650 LITER (65 KILOGRAM) PPB 45 PERCENT Cl 6.4 LITER / HOUR (EQN) HT 70 HOUR SOLUBILITY SOLUBLE IN WATER | GLUTAMATE [NMDA] RECEPTOR SUBUNIT 5HT3 RECEPTOR NICOTINIC ACETYLCHOLINE RECEPTOR PDB 4TWD (X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH MEMANTINE) LIGAND CODE = 377 (link to the list of PDB complexes) Download experimental 3D coordinates of 377 with added hydrogens | Glutamate receptor ionotropic, NMDA 3A UNIPROT Q8TCU5 GRIN3A -- Glutamate receptor ionotropic, NMDA 1 UNIPROT Q05586 GRIN1 more at DrugCentral | EMA | |||
