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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IBANDRONATE
| IBANDRONATE | MUSCULO-SKELETAL SYSTEM | ORAL INTRAVENOUS INJECTION | Tmax 1 HOUR F 0.6 PERCENT VD 90 LITER PPB 86 PERCENT Cl 5 LITER / HOUR HT 97 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | FARNESYL PYROPHOSPHATE SYNTHASE PDB 4UMJ (NATIVE STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHASE FROM PSEUDOMONAS AERUGINOSA PA01, WITH BOUND IBANDRONIC ACID MOLECULES.) LIGAND CODE = BFQ (link to the list of PDB complexes) Download experimental 3D coordinates of BFQ with added hydrogens | Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS more at DrugCentral | EMA | |||
