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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PREGABALIN
| PREGABALIN | NERVOUS SYSTEM | ORAL | Tmax 1.5 HOUR F 90 PERCENT VD 32.5 LITER (65 KILOGRAM) PPB 0 PERCENT Cl 3.7 LITER / HOUR (EQN) HT 6 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | ALPHA2-DELTA SITE OF VOLTAGE-GATED CALCIUM CHANNEL PDB 3JBR (CRYO-EM STRUCTURE OF THE RABBIT VOLTAGE-GATED CALCIUM CHANNEL CAV1.1 COMPLEX AT 4.2 ANGSTROM) | Voltage-dependent calcium channel subunit alpha-2,delta-1 UNIPROT P54289 CACNA2D1 -- Voltage-dependent calcium channel subunit alpha-2,delta-2 UNIPROT Q9NY47 CACNA2D2 more at DrugCentral | EMA | |||
