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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ATOMOXETINE
| ATOMOXETINE | NERVOUS SYSTEM | ORAL | Tmax 1.5 HOUR F 63 PERCENT VD 55 LITER (65 KILOGRAM) PPB 98 PERCENT Cl 22.7 LITER / HOUR HT 5.2 HOUR SOLUBILITY IN WATER 27.8 MILLIGRAM / MILLILITER | NORADRENALINE TRANSPORTER PDB 8ZP2 (CRYO-EM STRUCTURE OF HUMAN NOREPINEPHRINE TRANSPORTER NET BOUND WITH ATOMOXETINE IN AN OUTWARD-OPEN STATE AT A RESOLUTION OF 2.4 ANGSTROM) LIGAND CODE = A1LX4 (link to the list of PDB complexes) Download experimental 3D coordinates of A1LX4 with added hydrogens | Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
