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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GEFITINIB
| GEFITINIB | ANTINEOPLASTIC | ORAL | Tmax 5 HOUR F 60 PERCENT VD 1400 LITER PPB 90 PERCENT Cl 35.7 LITER / HOUR HT 48 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER ABOVE PH 7 | EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PDB 5Y7Z (COMPLEX STRUCTURE OF CYCLIN G-ASSOCIATED KINASE WITH GEFITINIB) LIGAND CODE = IRE (link to the list of PDB complexes) Download experimental 3D coordinates of IRE with added hydrogens | Epidermal growth factor receptor UNIPROT P00533 EGFR more at DrugCentral | EMA | |||
