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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TADALAFIL
| TADALAFIL |
GENITO | ORAL | Tmax 2 HOUR VD 63 LITER PPB 94 PERCENT Cl 2.5 LITER / HOUR HT 17.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 5 PDB 1XOZ (CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH TADALAFIL) LIGAND CODE = CIA (link to the list of PDB complexes) Download experimental 3D coordinates of CIA with added hydrogens | cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A more at DrugCentral | EMA | |||
