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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RIFAXIMIN
| RIFAXIMIN | METABOLISM | ORAL | Cmax 4.33 NANOMOLAR (200 MG THREE TIMES DAILY 3 DAYS) Tmax 0.8 HOUR PPB 67.5 PERCENT HT 1.8 HOUR | DNA-DEPENDANT RNA POLYMERASE BETA CHAIN PDB 6BEE (CRYSTAL STRUCTURE OF VACV D13 IN COMPLEX WITH RIFAXIMIN) LIGAND CODE = RXM (link to the list of PDB complexes) Download experimental 3D coordinates of RXM with added hydrogens | Bacterial DNA-directed RNA polymerase UNIPROT P0A7Z4 rpoA more at DrugCentral | EMA | |||
