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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VALDECOXIB DISCONTINUED
| VALDECOXIB | MUSCULO-SKELETAL SYSTEM | ORAL | Cmax 513 NANOMOLAR Tmax 3 HOUR F 83 PERCENT VD 86 LITER PPB 98 PERCENT Cl 6 LITER / HOUR HT 8.11 HOUR SOLUBILITY RELATIVELY INSOLUBLE IN WATER (10 MICROGRAM / MILLILITER AT 25 DEGREE CELSIUS AND PH 7.0 | PROSTAGLANDIN G/H SYNTHASE 2 PDB 2AW1 (CARBONIC ANHYDRASE INHIBITORS: VALDECOXIB BINDS TO A DIFFERENT ACTIVE SITE REGION OF THE HUMAN ISOFORM II AS COMPARED TO THE STRUCTURALLY RELATED CYCLOOXYGENASE II "SELECTIVE" INHIBITOR CELECOXIB) LIGAND CODE = COX (link to the list of PDB complexes) Download experimental 3D coordinates of COX with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 more at DrugCentral | EMA | |||
