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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BOSENTAN
| BOSENTAN | CARDIOVASCULAR | ORAL | Tmax 4 HOUR F 50 PERCENT VD 18 LITER PPB 98 PERCENT Cl 4 LITER / HOUR HT 5 HOUR SOLUBILITY POORLY SOLUBLE IN WATER | ENDOTHELIN RECEPTOR ENDOTHELIN-1 RECEPTOR PDB 5XPR (HUMAN ENDOTHELIN RECEPTOR TYPE-B IN COMPLEX WITH ANTAGONIST BOSENTAN) LIGAND CODE = K86 (link to the list of PDB complexes) Download experimental 3D coordinates of K86 with added hydrogens | Endothelin-1 receptor UNIPROT P25101 EDNRA -- Endothelin B receptor UNIPROT P24530 EDNRB more at DrugCentral | EMA | |||
