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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| METHIMAZOLE
| METHIMAZOLE | HORMONES | ORAL | Cmax 1.3 MICROMOLAR (10 MILLIGRAM , PMID6642787) Tmax 0.9 HOUR VD 136 LITER (65 KILOGRAM , PMID3830069) Cl 4.6 LITER / HOUR (65 KILOGRAM) HT 5.4 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | PDB 2GVC (CRYSTAL STRUCTURE OF FLAVIN-CONTAINING MONOOXYGENASE (FMO)FROM S.POMBE AND SUBSTRATE (METHIMAZOLE) COMPLEX) LIGAND CODE = MMZ (link to the list of PDB complexes) Download experimental 3D coordinates of MMZ with added hydrogens | Thyroid peroxidase UNIPROT P07202 TPO more at DrugCentral | EMA | |||
