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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TREPROSTINIL
| TREPROSTINIL | BLOOD | IV SUBCUTANEOUS INHALATION ORAL INTRAVENOUS | Cmax 3.4 NANOMOLAR Tmax 0.12 HOUR F 72 PERCENT VD 13 LITER (65 KILOGRAM) PPB 91 PERCENT Cl 27.8 LITER / HOUR (65 KILOGRAM) HT 4 HOUR | PROSTACYCLIN RECEPTOR PDB 8X7A (TREPROSTINIL BOUND PROSTACYCLIN RECEPTOR G PROTEIN COMPLEX) LIGAND CODE = Y9J (link to the list of PDB complexes) Download experimental 3D coordinates of Y9J with added hydrogens | Prostacyclin receptor UNIPROT P43119 PTGIR more at DrugCentral | EMA | |||
