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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
APOMORPHINE

APOMORPHINE


ATC G04BE07
ATC N04BC07

NERVOUS SYSTEM
ANTIDYSKINETICS
ANTIPARKINSON AGENTS
NON-ERGOLINE DOPAMINE AGONIST D4 (KI = 4.4 NANOMOLAR) D2 (KI = 35 NANOMOLAR) D3 (KI = 26 NANOMOLAR) D5 (KI = 15 NANOMOLAR)

SUBCUTANEOUS SUBLINGUAL

F 100 PERCENT

VD 218 LITER

PPB 94 PERCENT

Cl 223 LITER / HOUR

HT 0.66 HOUR

SOLUBILITY SOLUBLE IN WATER

DOPAMINE D2 RECEPTOR

PDB 7JVQ (CRYO-EM STRUCTURE OF APOMORPHINE-BOUND DOPAMINE RECEPTOR 1 IN COMPLEX WITH GS PROTEIN)

LIGAND CODE = OR9 (link to the list of PDB complexes)

Download experimental 3D coordinates of OR9 with added hydrogens

D(2) dopamine receptor UNIPROT P14416 DRD2

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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