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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TELITHROMYCIN DISCONTINUED

TELITHROMYCIN


ATC J01FA15

ANTIINFECTIVES
ANTIBIOTIC
ANTI-BACTERIAL AGENTS
KETOLIDE
BINDING TO DOMAINS II AND V OF 23S RRNA OF THE 50S RIBOSOMAL SUBUNIT

ORAL

Cmax 2.46 MICROMOLAR

Tmax 1 HOUR

F 57 PERCENT

VD 188 LITER

PPB 65 PERCENT

Cl 54.6 LITER / HOUR (65 KILOGRAM)

HT 10 HOUR

50S RIBOSOMAL SUBUNIT

PDB 4V7Z (STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH TELITHROMYCIN.)

LIGAND CODE = TEL (link to the list of PDB complexes)

Download experimental 3D coordinates of TEL with added hydrogens

Unknown

more at DrugCentral

EMA

ANSM (in French)

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Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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