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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PROGUANIL (has an active metabolite)
| PROGUANIL |
ANTIPARASITIC | ORAL | Tmax 3.5 HOUR VD 2059 LITER PPB 75 PERCENT Cl 67.9 LITER / HOUR HT 16.5 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | DIHYDROFOLATE REDUCTASE | Bifunctional dihydrofolate reductase-thymidylate synthase UNIPROT P13922 more at DrugCentral | EMA | |||
