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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RIFAPENTINE (has an active metabolite)
| RIFAPENTINE | ANTIINFECTIVES | ORAL | Cmax 17.1 MICROMOLAR Tmax 5.5 HOUR F 70 PERCENT VD 70 LITER PPB 97.7 PERCENT Cl 2.03 LITER / HOUR HT 13 HOUR | DNA-DIRECTED RNA POLYMERASE PDB 2A69 (CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFAPENTIN) LIGAND CODE = RPT (link to the list of PDB complexes) Download experimental 3D coordinates of RPT with added hydrogens | Bacterial DNA-directed RNA polymerase UNIPROT P0A7Z4 rpoA more at DrugCentral | EMA | |||
