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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMPRENAVIR DISCONTINUED (is an active metabolite)
| AMPRENAVIR | ANTIINFECTIVES | ORAL | Cmax 8.23 MICROMOLAR Tmax 1.3 HOUR PPB 90 PERCENT HT 7.7 HOUR | HIV-1 PROTEASE PDB 4JEC (JOINT NEUTRON AND X-RAY STRUCTURE OF PER-DEUTERATED HIV-1 PROTEASE IN COMPLEX WITH CLINICAL INHIBITOR AMPRENAVIR) LIGAND CODE = 478 (link to the list of PDB complexes) Download experimental 3D coordinates of 478 with added hydrogens | Pol polyprotein UNIPROT Q72874 pol more at DrugCentral | EMA | |||
