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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RABEPRAZOLE
| RABEPRAZOLE |
METABOLISM | ORAL | Cmax 1.84 MICROMOLAR (PMID18621671) Tmax 3.5 HOUR F 52 PERCENT VD 14.3 LITER (65 KILOGRAM) PPB 96.3 PERCENT Cl 15.6 LITER / HOUR (65 KILOGRAM) HT 1.5 HOUR SOLUBILITY VERY SOLUBLE IN WATER | POTASSIUM-TRANSPORTING ATPASE PDB 3PGL (CRYSTAL STRUCTURE OF HUMAN SMALL C-TERMINAL DOMAIN PHOSPHATASE 1 (SCP1) BOUND TO RABEPRAZOLE) LIGAND CODE = RZX (link to the list of PDB complexes) Download experimental 3D coordinates of RZX with added hydrogens | Potassium-transporting ATPase UNIPROT P20648 ATP4A more at DrugCentral | EMA | |||
