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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| EFAVIRENZ
| EFAVIRENZ |
ANTIINFECTIVES | ORAL | Cmax 5.35 MICROMOLAR Tmax 5 HOUR PPB 99.6 PERCENT HT 64 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | HIV-1 REVERSE TRANSCRIPTASE PDB 6BSJ (STRUCTURE OF HIV-1 RT COMPLEXED WITH AN RNA, DNA HYBRID SEQUENCE NON-PREFERRED FOR RNA HYDROLYSIS) LIGAND CODE = EFZ (link to the list of PDB complexes) Download experimental 3D coordinates of EFZ with added hydrogens | Reverse transcriptase,RNaseH UNIPROT Q72547 pol more at DrugCentral | EMA | |||
