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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TIROFIBAN
| TIROFIBAN | BLOOD | INJECTION INTRAVENOUS | VD 32 LITER PPB 65 PERCENT Cl 15.8 LITER / HOUR HT 2 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | PLATELET GLYCOPROTEIN (PG) IIB/IIIA PDB 2VDM (RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN) LIGAND CODE = AGG (link to the list of PDB complexes) Download experimental 3D coordinates of AGG with added hydrogens | Integrin alpha-IIb,beta-3 UNIPROT P05106 ITGB3 more at DrugCentral | EMA | |||
