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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ALITRETINOIN
| ALITRETINOIN | ANTINEOPLASTIC | TOPICAL | Tmax 3.5 HOUR PPB 99 PERCENT HT 6 HOUR SOLUBILITY INSOLUBLE IN WATER | RETINOIC X RECEPTOR (RXR) RETINOIC ACID RECEPTOR (RAR) PDB 5UAN (CRYSTAL STRUCTURE OF MULTI-DOMAIN RAR-BETA-RXR-ALPHA HETERODIMER ON DNA) LIGAND CODE = 9CR (link to the list of PDB complexes) Download experimental 3D coordinates of 9CR with added hydrogens | Retinoic acid receptor alpha UNIPROT P10276 RARA -- Retinoic acid receptor RXR-alpha UNIPROT P19793 RXRA more at DrugCentral | EMA | |||
